PENICILLIN 20 - STREPTOMYCIN 20 Injectable solution
COMPOSITION (per ml):
Procaine penicillin G 200.000 IU
Dihydrostreptomycin base (as sulfate) 200 mg
Procaine hydrochloride 20 mg
PHARMACOLOGICAL PROPERTIES
This product consists procaine penicillin G and sulfate dihydrostreptomycin, which combination, often, appears synergia of antibacterial action. Procaine penicillin G is penicillin of small spectrum, with bactericidal action against GRAM(+) bacterias. Streptococcus (Str.viridans, Str.faecalis), negative at penicillinase staphylococcus, Corynebacterium spp., Listeria monocytogenes, Bacillus anthracis, Haemophilus spp., Pasteurella spp., Clostridia, Erysipelothrix rhusiopathiae, Actinomyces and obligatory anaerobe microorganisms (as Bacteroides spp., Fusobacterium necrophorum) are sensitive to it. Non-sensitive are staphylococcus that produce penicillinase, pseudomonas enterobacteria and proteus. The development of bacteria resistance is caused by the ability of the bacteria to produce penicillinase, generally. Dihydrostreptomycin has a bactericidal action, mostly, against GRAM(-) bacterias. Sensitive to it are the following bacterias: Pasteurella spp., Mycobacterium spp., Brucella spp and staphylococcus. Non-sensitive are various strain of Pseudomonas. The resistance of bacterias to dihydrostreptomycin can develop quickly, due to the production of inactivating enzymes.
TARGET SPECIES
Dogs, cats.
INDICATIONS
Treatment of general infection caused by GRAM(+) and GRAM(-) bacterias, sensitive to the combination of procaine penicillin G and dihydrostreptomycin.
DOSAGE AND METHOD OF ADMINISTRATION
It is administered by intramuscular injection.
Dogs, cats: 1 ml of product per 10 kg of body weight
If necessary, the dosage can be repeated for the next 3-5 days.
CONTRAINDICATIONS
Do not administer to:
Animals with hypersensitivity to penicillins and aminoglycosides
Animals with serious renal disorders, and neurological symptoms (paresthesia, auditive or other disorders)
Small herbivorous (they are sensitive to penicillins) and to other animals that are not included to target species
UNDESIRABLE EFFECTS
o Hypersensitivity reactions (allergic and anaphylactic)
o Neurotoxic disorders (visceral disorders, paresthesis, non reversible disorders of vestibular and auditive organ)
o Nephrotoxic disorders (their frequency depends on the quantity of the dosage and the duration of the treatment.).
o Local irritation at the spot of the injection, after injection of great quantities.
o Allergic reactions are controlled by use of antistaminic products or epinephrine.
INTERACTION WITH OTHER MEDICAMENTS
Simultaneous administration with bacteriostatic antibiotics (tetracyclines) must be avoided. Also, do not administer simultaneously with nephrotoxic substances.
INCOMPATIBILITY
Not mentioned
OVERDOSE
Hypersensitivity reactions, renal disorders, hypotension, bradycardia, audition loss.
USE DURING PREGNANCY AND LACTATION
No undesirable effects are mentioned, if the product is administered at the recommended dosage.
WITHDRAWAL TIME
Not applicable
SPECIAL PRECAUTIONS FOR USE
Do not administer intravenously, because it can cause severe anaphylactic shock or thrombophlebitis. Shake well before use. You should proceed to a control check of benzylopenicillin (sensitivity test), before the use of the product.
SPECIAL PRECAUTIONS TO BE TAKEN BY THE PERSON ADMINISTERING THE PRODUCT TO ANIMALS
People who use this product must use gloves and face masks specially in case known hypersensitivity to penicillins.
STORAGE AND SHELF LIFE
2 years in a cool place (6-150 C)
SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIAL, IF ANY:
Not mentioned
PACKAGE
Glass flacons of 100 ml & 250 ml.
