Neocell

OXYTETRACYCLINE L.A. 20% Injectable solution

COMPOSITION (per ml):  
Oxytetracycline base  (as dihydrate)                    200mg

PHARMACOLOGICAL PROPERTIES
Oxytetracycline L.A 20%is a broad-spectrum bacteriostatic, with antibacterial action against GRAM + and GRAM - bacterias, except from species of Pseudomonas, Klebsiella and Proteus. Also, the antibacterial spectrum includes leptospires, spirochaetes, actinomyces, riketsias, chlamydias, some mycoplasmas and some protozoon. The bacteriostatic action of oxytetracycline is due to the inhibition of metabolism of glutaminic acid, resulting in the inhibition of synthesis of bacterial proteins. Bacterial resistance at tetracyclines develop many species of bacterias. Especially, resistance show species of Pseudomonas, Klebsiella, Proteus, Aerobacter, and Enterococci. Also, among tetracyclines, there is crossed resistance.  The excretion of oxytetracycline becomes via the renal pathway with the non-metabolism form and partial via the bile. To the dairy animals, excretion becomes via the milk also.   

TARGET SPECIES
Caws, calves, pigs

INDICATIONS
It is administered for treatment of infections, caused by microorganisms sensitive at oxyteracycline and especially.
Cows: Indications of metritis development (an injection is applied after labor)
Calves: Treatment of respiratory diseases (disease of transportation and pneumonia by Pasteurella multocida and P.haemolytica). In these cases one (1) injection is enough.
Pigs: Treatment of pneumonia caused by Haemophilus pneumoniae (1 injection)

DOSAGE AND METHOD OF ADMINISTRATION
It is administered only intramuscularly in single dose. Generally, the quantity of injection is 20 mg oxytetracycline per kg of body weight. Quantities greater than 10 ml should be injected in two different spots.

CONTRAINDICATIONS
Do not administer to animals with known hypersensitivity to tetracyclines and, to animals with renal or hepatic insufficiency.

UNDESIRABLE EFFECTS
•    Hypersensitivity reactions
•    Local irritation at the area of the injection, that passes after approximately 5 days.
•    Discoloration of developing teeth

INTERACTION WITH OTHER MEDICINES
Do not administer simultaneously with penicillins and kephalosporines, because of the observed competition. The administration simultaneously with digoxine, or barfarine, reinforces their action. The administration simultaneously with methoxyphlurane increases its nephrotoxic action.  

INCOMPATIBILITY
Not mentioned.

OVERDOSE
Not mentioned.

USE DURING PREGNANCY AND LACTATION
Do not be administered during the last 2 months of pregnancy.

SPECIAL PRECAUTIONS FOR USE
It is recommended to become an antibiogram before use, for the ascertainment of sensitivity of the responsible bacteria to the oxytetracycline. After intravenous injection, may be caused thrombophlebitis.

WITHDRAWAL TIME
Meat (cattle, pigs):  28 days
Milk(cows):                7 days

STORAGE AND SELF-LIFE
2 years when the product is stored in a cool place. After the first use the product remains stable for 30 days.

SPECIAL PRECAUTIONS FOR THE DISPOSAL OF UNUSED PRODUCT OR WASTE MATERIAL, IF ANY:
Not mentioned

PACKAGE
Glass flacons of 100ml.