Qualitative and quantitatiνe composition (per package)
Lyophilized tablet 500 IU 1000 IU 3000IU 5000 IU 6000IU
Pregnant Mare’s Serum
gonadotrophin 500 1000 3000 5000 6000 IU
Disodium phosphate 0,5 1 3 5 6mg
dodecahydrate
Sodium dihydrogen 0,5 1 3 5 6mg
phosphate
Mannitol 25 50 150 250 300mg
Diluent
Water for injections up to 2 4 12 20 24 ml
Pharmaceutical form
Powder and diluent for injectable solution
Target species
Caws, mares, ewes, goats, sows, bitches, female cats and female rabbits.
Indications
In all target species for stimulating the ovarian function and activity, for the fertility improvement to the animals that go through estrus synchronization and for multiple ovulations to the embryo transfer. Usually it occludes with other treatments.
Contra-indications
- Do not administer in case of females with polycysts in ovaries.
- It is not advisable to be fertilisized animals in which estrus has been induced, if the case of the polycysts in ovaries has not been excluded. (Specific in case of uniparous animals)
- Do not administer in cases of cardiac and hepatic insufficiency.
Special precautions for each target specie
To the animals, which has been generate estrus by PMSG is possible to present multiple ovulation and fertilization more than one ovule. That fact must be taken notice of in case of uniparous animals. The hormone action may be varied in proportion to the lactation stage or the breed
Special precautions for use
To be kept all the antisepsis conditions during the injection
Undesirable effects
- Hyperstimulation of the ovaries.
- Hypersensivity reactions that can handle by corticosteroides or adrenaline administration.
- The repeating use of PMSG can reduce the efficacy inasmuch is not easy to determinate.
Use during pregnancy and lactation
Do not administer to pregnant females.
Interactions with other medicaments
There is no information relatively the insurance and the efficacy from the use of this product with any other medicine.
Administration and route of administration
Immediately after the reconstitution the product is injected intramuscularly as follows:
Cows-Mares: 200-2500I.U, equivalent to 0,8-10ml CELL0GEST in single dose
Ewes and Goats: 100-500 I.U, equivalent to 0,4-2ml CELLOGEST in single dose It’s difficult to quantify the dosage. Little doses potentially can cause dysfunction to the regular ovulation but overdoses can cause undesirable or dangerous pregnancy including multiple embryos. In any case dosage is individualized in proportion to the result that is requested and the type of the treatment that is applied.
Sows: 200-800 IU equivalent to 0,8-3,2 ml CELLOGEST in single dose
Bitches: 25-200 IU equivalent to 0,1-0,8 ml CELLOGEST
Female cats: 25-100 IU equivalent to 0,1-0,5 ml CELLOGEST
Female rabbits: 25-100 IU equivalent to 0,1-0,5 ml CELLOGEST
Relatively to bitches and female cats usually a single dose is not enough.
The administration rate is based in prescribed protocol.
Overdose
In case of overdose the undesirable effects will be increased
Withdrawal time
Meat (cows-mares-ewes-goats-sows-rabbits) : Zero days
Milk (cows-ewes-goats) : Zero days
Incompatibilities
Do not compound with other medicaments
Self-life
- Lyophilized product : 2 years, stored in temperature 2o – 8o C in dry and dark place
- Reconstituted product : The reconstituted product must be used immediately. The disposal of unused product must be made away immediately
Special precautions for storage
It is stored in dark, dry, cool and dark place (2o – 8o C).
Package
Vials 500 IU with diluent of 2 ml, 1000 IU with diluent of 4 ml, 3000 IU with diluent of 12 ml, 5000 IU with diluent of 20 ml, 6000 IU with diluent 24 ml and package of 5 x 1000 IU PMSG with diluents 5 x 4 ml.